2P85

Structure of Human Lung Cytochrome P450 2A13 with indole bound in two alternate conformations

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Cytochrome P450 2A13	polymer	476	54804.8	6	UniProt (Q16696) Pfam (PF00067)	Homo sapiens (human)	CYPIIA13
2	G, J, M, P, S... (A, B, C, D, E...)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	6	Chemie (HEM)
3	H, I, K, L, N... (A, B, C, D, E...)	INDOLE	non-polymer		117.1	12	Chemie (IND)
4	AA, BA, CA, DA, Y... (C, D, E, F, A...)	water	water		18.0	597	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 23 - 494 (UniProt: Q16696)

PDB	External Database	Details
Met 23	Val 23	engineered mutation
Ala 24	Trp 24	engineered mutation
Lys 25	Arg 25	engineered mutation
Lys 26	Gln 26	engineered mutation
Thr 27	Arg 27	engineered mutation
Ser 28	Lys 28	engineered mutation
Lys 30	Arg 30	engineered mutation
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	328828.5
Non-Polymers*	Number of molecules	18
	Total formula weight	5104.7
All*	Total formula weight	333933.2

*Water molecules are not included.