2P5W
Crystal structures of high affinity human T-cell receptors bound to pMHC reveal native diagonal binding geometry
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 276 | 31951.3 | 1 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | Homo sapiens (human) | MHC class I antigen A*2 |
| 2 | B (B) | Beta-2-microglobulin | polymer | 100 | 11853.3 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | C (C) | Cancer/testis antigen 1B | polymer | 9 | 1094.3 | 1 | UniProt (P78358) | L antigen family member 2, LAGE-2 protein, Autoimmunogenic cancer/testis antigen NY-ESO-1 | |
| 4 | D (D) | T-CELL RECEPTOR, ALPHA CHAIN | polymer | 192 | 21073.4 | 1 | UniProt (Q6PIZ8) Pfam (PF09291) UniProt (by SIFTS) (P01848) | Homo sapiens (human) | |
| 5 | E (E) | Hypothetical protein | polymer | 243 | 27367.5 | 1 | UniProt (Q2YDB4) | Homo sapiens (human) | |
| 6 | F, G, H, O, R... (A, B, D, E) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 7 | I, J, K, L, P... (A, B, D, E) | GLYCEROL | non-polymer | 92.1 | 11 | Chemie (GOL) | |||
| 8 | M (B) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 9 | N (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 10 | X (E) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 11 | AA, BA, CA, DA, Z (B, C, D, E, A) | water | water | 18.0 | 675 | Chemie (HOH) |
Sequence modifications
B: 2 - 99 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | insertion |
| Cys 91 | Lys 111 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 93339.9 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 1892.1 | |
| All* | Total formula weight | 95232.0 |
