2P1D

Crystal structure of dengue methyltransferase in complex with GTP and S-Adenosyl-L-homocysteine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	type II methyltransferase	polymer	305	34397.0	1	UniProt (Q9WLZ8) Pfam (PF01728) UniProt (by SIFTS) (P12823)	Dengue virus 2
2	B, C, D, E, F... (A)	SULFATE ION	non-polymer		96.1	10	Chemie (SO4)
3	L (A)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	1	Chemie (SAH)
4	M (A)	GUANOSINE-5'-MONOPHOSPHATE	non-polymer		363.2	1	Chemie (5GP)
5	N (A)	water	water		18.0	11	Chemie (HOH)

Sequence modifications

A: 4 - 296 (UniProt: Q9WLZ8)

PDB	External Database	Details
Met -8	-	expression tag
Arg -7	-	expression tag
Gly -6	-	expression tag
Ser -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Gly 2	-	expression tag
Ser 3	-	expression tag
Leu 70	Met 2561	SEE REMARK 999
Arg 139	Lys 2630	SEE REMARK 999
Ser 173	Asn 2664	SEE REMARK 999
Val 180	Ile 2671	SEE REMARK 999
Ser 188	Pro 2679	SEE REMARK 999
His 201	Tyr 2692	SEE REMARK 999
Thr 271	Ile 2762	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34397.0
Non-Polymers*	Number of molecules	12
	Total formula weight	1708.3
All*	Total formula weight	36105.3

*Water molecules are not included.