2P15
Crystal structure of the ER alpha ligand binding domain with the agonist ortho-trifluoromethylphenylvinyl estradiol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Estrogen receptor | polymer | 258 | 29386.6 | 2 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (human) | ER, Estradiol receptor, ER-alpha |
| 2 | C, D | GRIP peptide | polymer | 13 | 1579.9 | 2 | UniProt (Q15596) In PDB | ||
| 3 | A, B | (17BETA)-17-{(E)-2-[2-(TRIFLUOROMETHYL)PHENYL]VINYL}ESTRA-1(10),2,4-TRIENE-3,17-DIOL | non-polymer | 442.5 | 2 | Chemie (EZT) | |||
| 4 | water | water | 18.0 | 461 | Chemie (HOH) |
Sequence modifications
A, B: 298 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 297 | - | cloning artifact |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 61932.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 885.0 | |
| All* | Total formula weight | 62818.0 |
