2OX0

Crystal structure of JMJD2A complexed with histone H3 peptide dimethylated at Lys9

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	JmjC domain-containing histone demethylation protein 3A	polymer	381	44326.3	2	UniProt (O75164) Pfam (PF02375) Pfam (PF02373)	Homo sapiens (human)	Jumonji domain-containing protein 2A
2	C, D (C, D)	synthetic peptide	polymer	8	875.0	2	UniProt (by SIFTS) (P68431)
3	E, I (A, B)	NICKEL (II) ION	non-polymer		58.7	2	Chemie (NI)
4	F, J (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	G (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6	H, K (A, B)	N-OXALYLGLYCINE	non-polymer		147.1	2	Chemie (OGA)
7	L, M, N, O (A, B, C, D)	water	water		18.0	483	Chemie (HOH)

Sequence modifications

A, B: 1 - 359 (UniProt: O75164)

PDB	External Database	Details
Met -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	90402.6
Non-Polymers*	Number of molecules	7
	Total formula weight	577.8
All*	Total formula weight	90980.4

*Water molecules are not included.