2OWB
Structure of the Catalytic Domain of Human Polo-like Kinase 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase PLK1 | polymer | 335 | 37634.8 | 1 | UniProt (P53350) Pfam (PF00069) | Homo sapiens (human) | Polo-like kinase 1, PLK-1, Serine/threonine-protein kinase 13, STPK13 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C, D (A) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 4 | E (A) | 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE | non-polymer | 448.5 | 1 | Chemie (626) | |||
| 5 | F (A) | water | water | 18.0 | 256 | Chemie (HOH) |
Sequence modifications
A: 13 - 345 (UniProt: P53350)
| PDB | External Database | Details |
|---|---|---|
| Gly 11 | - | cloning artifact |
| Pro 12 | - | cloning artifact |
| Val 210 | Thr 210 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37634.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 632.0 | |
| All* | Total formula weight | 38266.8 |
