2OUR
crystal structure of PDE10A2 mutant D674A in complex with cAMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 331 | 38262.1 | 2 | UniProt (Q9Y233) Pfam (PF00233) | Homo sapiens (human) | |
| 2 | C, E (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 3 | D (A) | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | non-polymer | 329.2 | 1 | Chemie (CMP) PubChem (6076) PubChem (176488666) PubChem (216878) PubChem (23902375) PubChem (25322948) PubChem (40467852) PubChem (44629928) PubChem (25322946) PubChem (3080770) PubChem (56973690) PubChem (3246347) PubChem (59909322) PubChem (59968988) PubChem (59350541) PubChem (70878457) PubChem (274) PubChem (6603718) PubChem (6713792) PubChem (6714006) PubChem (12071879) PubChem (12866365) PubChem (6604194) PubChem (124132380) PubChem (129317551) PubChem (131841987) PubChem (134693155) PubChem (163043517) PubChem (138107790) PubChem (163043518) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 433 | Chemie (HOH) |
Sequence modifications
A, B: 449 - 776 (UniProt: Q9Y233)
| PDB | External Database | Details |
|---|---|---|
| Ser 446 | - | cloning artifact |
| His 447 | - | cloning artifact |
| Met 448 | - | cloning artifact |
| Ala 674 | Asp 664 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 76524.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 377.8 | |
| All* | Total formula weight | 76901.9 |
