2OIC
Crystal structure of IRAK4 kinase domain complexed with staurosporine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Interleukin-1 receptor-associated kinase 4 | polymer | 301 | 33956.2 | 4 | UniProt (Q9NWZ3) Pfam (PF07714) | Homo sapiens (human) | IRAK-4, NY- REN-64 antigen |
| 2 | E, F, G, H (A, B, C, D) | STAUROSPORINE | non-polymer | 466.5 | 4 | Chemie (STU) PubChem (5279) PubChem (44259) PubChem (451705) PubChem (5459111) PubChem (6419748) PubChem (9804568) PubChem (9937179) PubChem (71203703) PubChem (42610657) PubChem (44299148) PubChem (25322871) PubChem (28684983) PubChem (49831000) PubChem (44120114) PubChem (44537813) PubChem (46864193) PubChem (358479) PubChem (5280487) PubChem (5311103) PubChem (6711321) PubChem (9956178) PubChem (12046017) PubChem (68262703) PubChem (68306294) PubChem (73953205) PubChem (86306248) PubChem (122130844) PubChem (143163481) PubChem (143224059) PubChem (143494026) PubChem (162978898) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 269 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 160 - 460 (UniProt: Q9NWZ3)
| PDB | External Database | Details |
|---|---|---|
| Tpo 342 | Thr 342 | modified residue |
| Tpo 345 | Thr 345 | modified residue |
| Sep 346 | Ser 346 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 135824.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1866.1 | |
| All* | Total formula weight | 137690.9 |
