2OG8
crystal structure of aminoquinazoline 36 bound to Lck
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Proto-oncogene tyrosine-protein kinase LCK | polymer | 265 | 30517.0 | 2 | UniProt (P06239) Pfam (PF07714) In PDB | Homo sapiens (human) | p56-LCK, Lymphocyte cell-specific protein-tyrosine kinase, LSK, T cell- specific protein-tyrosine kinase |
| 2 | A, B | N-{2-[(N,N-DIETHYLGLYCYL)AMINO]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[2-(METHYLAMINO)QUINAZOLIN-6-YL]BENZAMIDE | non-polymer | 564.6 | 2 | Chemie (1N8) | |||
| 3 | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A, B: 237 - 499 (UniProt: P06239)
| PDB | External Database | Details |
|---|---|---|
| Asp 236 | - | cloning artifact |
| Ala 500 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 61033.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1129.2 | |
| All* | Total formula weight | 62163.1 |
