2OFU
x-ray crystal structure of 2-aminopyrimidine carbamate 43 bound to Lck
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proto-oncogene tyrosine-protein kinase LCK | polymer | 273 | 31651.1 | 1 | UniProt (P06239) Pfam (PF07714) | Homo sapiens (human) | p56-LCK, Lymphocyte cell-specific protein-tyrosine kinase, LSK, T cell- specific protein-tyrosine kinase |
| 2 | B (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | C (A) | 2,6-DIMETHYLPHENYL 2-(3,5-DIMETHOXY-4-(3-(4-METHYLPIPERAZIN-1-YL)PROPOXY)PHENYLAMINO)PYRIMIDIN- 4-YL(2,4-DIMETHOXYPHENYL)CARBAMATE | non-polymer | 686.8 | 1 | Chemie (1N9) | |||
| 4 | D (A) | water | water | 18.0 | 312 | Chemie (HOH) |
Sequence modifications
A: 229 - 501 (UniProt: P06239)
| PDB | External Database | Details |
|---|---|---|
| Ptr 394 | Tyr 393 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31651.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 782.9 | |
| All* | Total formula weight | 32434.0 |
