2O8E
human MutSalpha (MSH2/MSH6) bound to a G T mispair, with ADP bound to MSH2 only
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | 5'-D(*GP*AP*AP*CP*CP*GP*CP*GP*GP*GP*CP*TP*AP*GP*G)-3' | polymer | 15 | 4660.0 | 1 | |||
| 2 | B (F) | 5'-D(*CP*CP*TP*AP*GP*CP*CP*TP*GP*CP*GP*GP*TP*TP*C)-3' | polymer | 15 | 4536.9 | 1 | |||
| 3 | C (A) | DNA mismatch repair protein Msh2 | polymer | 934 | 104785.8 | 1 | UniProt (P43246) Pfam (PF01624) Pfam (PF05188) Pfam (PF05192) Pfam (PF05190) Pfam (PF00488) | Homo sapiens (human) | MutS protein homolog 2 |
| 4 | D (B) | DNA mismatch repair protein MSH6 | polymer | 1022 | 116056.7 | 1 | UniProt (P52701) Pfam (PF00488) Pfam (PF01624) Pfam (PF05188) Pfam (PF05192) Pfam (PF05190) | Homo sapiens (human) | MutS-alpha 160 kDa subunit, G/T mismatch-binding protein, GTBP, GTMBP, p160 |
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 7 | G (B) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A: 1 - 934 (UniProt: P43246)
B: 341 - 1360 (UniProt: P52701)
| PDB | External Database | Details |
|---|---|---|
| Ala 42 | Phe 42 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 339 | - | initiating methionine |
| Gly 340 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 230039.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 451.5 | |
| All* | Total formula weight | 230490.9 |
