2O8D
human MutSalpha (MSH2/MSH6) bound to ADP and a G dU mispair
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | 5'-D(*GP*AP*AP*CP*CP*GP*CP*GP*CP*GP*CP*TP*AP*GP*G)-3' | polymer | 15 | 4620.0 | 1 | |||
| 2 | B (F) | 5'-D(*CP*CP*TP*AP*GP*CP*GP*(DU)P*GP*CP*GP*GP*TP*TP*C)-3' | polymer | 15 | 4562.9 | 1 | |||
| 3 | C (A) | DNA mismatch repair protein Msh2 | polymer | 934 | 104861.9 | 1 | UniProt (P43246) Pfam (PF01624) Pfam (PF05188) Pfam (PF05192) Pfam (PF05190) Pfam (PF00488) | Homo sapiens (human) | MutS protein homolog 2 |
| 4 | D (B) | DNA mismatch repair protein MSH6 | polymer | 1022 | 116056.7 | 1 | UniProt (P52701) Pfam (PF00488) Pfam (PF01624) Pfam (PF05188) Pfam (PF05192) Pfam (PF05190) | Homo sapiens (human) | MutS-alpha 160 kDa subunit, G/T mismatch-binding protein, GTBP, GTMBP, p160 |
| 5 | E, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | F, H (A, B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 7 | I, J, K, L (E, F, A, B) | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
B: 341 - 1360 (UniProt: P52701)
| PDB | External Database | Details |
|---|---|---|
| Met 339 | - | initiating methionine |
| Gly 340 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 230101.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 903.0 | |
| All* | Total formula weight | 231004.5 |
