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2O88

Crystal structure of the N114A mutant of ABL-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BProto-oncogene tyrosine-protein kinase ABL1polymer586380.12UniProt (P00519)
Pfam (PF00018)
In PDB
Homo sapiens (human)p150, c- ABL, Abelson murine leukemia viral oncogene homolog 1
2C, DP41 peptidepolymer111035.12synthetic construct
3A, BSULFATE IONnon-polymer96.12Chemie (SO4)
4waterwater18.067Chemie (HOH)
Sequence modifications
A, B: 64 - 121 (UniProt: P00519)
PDBExternal DatabaseDetails
Ala 114Asn 114engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight14830.4
Non-Polymers*Number of molecules2
Total formula weight192.1
All*Total formula weight15022.5
*Water molecules are not included.

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PDB entries from 2024-07-31

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