2O61
Crystal Structure of NFkB, IRF7, IRF3 bound to the interferon-b enhancer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | 36-MER | polymer | 36 | 11269.3 | 1 | |||
| 2 | B (F) | 34-MER | polymer | 34 | 10255.6 | 1 | |||
| 3 | C (A) | Transcription factor p65/Interferon regulatory factor 7/Interferon regulatory factor 3 fusion protein | polymer | 540 | 61032.8 | 1 | UniProt (Q04206) UniProt (Q92985) UniProt (Q14653) Pfam (PF00554) Pfam (PF16179) Pfam (PF00605) | Homo sapiens (human) | |
| 4 | D (B) | Nuclear factor NF-kappa-B p105 subunit | polymer | 314 | 35179.2 | 1 | UniProt (P19838) Pfam (PF00554) Pfam (PF16179) | Homo sapiens (human) | DNA-binding factor KBF1, EBP-1 |
| 5 | E, F, G, H (E, F, A, B) | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
A: 20 - 291 (UniProt: Q04206)
A: 1008 - 1125 (UniProt: Q92985)
A: 2009 - 2111 (UniProt: Q14653)
B: 38 - 350 (UniProt: P19838)
| PDB | External Database | Details |
|---|---|---|
| Met 18 | - | initiating methionine |
| Gly 19 | - | cloning artifact |
| Gly 292 | - | linker |
| Ser 293 | - | linker |
| Leu 294 | - | linker |
| Ser 295 | - | linker |
| Ser 296 | - | linker |
| Gly 297 | - | linker |
| Ser 298 | - | linker |
| Ser 299 | - | linker |
| Leu 300 | - | linker |
| Ser 301 | - | linker |
| Ser 302 | - | linker |
| Pro 303 | - | linker |
| Ser 304 | - | linker |
| Ala 305 | - | linker |
| Gly 306 | - | linker |
| Gly 1126 | - | linker |
| Ser 1127 | - | linker |
| Leu 1128 | - | linker |
| Ser 1129 | - | linker |
| Ser 1130 | - | linker |
| Asp 1131 | - | linker |
| Ser 1132 | - | linker |
| Ser 1133 | - | linker |
| Leu 1134 | - | linker |
| Ser 1135 | - | linker |
| Ser 1136 | - | linker |
| Pro 1137 | - | linker |
| Ser 1138 | - | linker |
| Ala 1139 | - | linker |
| Leu 1140 | - | linker |
| Ser 1141 | - | linker |
| Pro 1142 | - | linker |
| Lys 1143 | - | linker |
| Pro 1144 | - | linker |
| Arg 1145 | - | linker |
| Ile 1146 | - | linker |
| Gly 2112 | - | expression tag |
| Leu 2113 | - | expression tag |
| Glu 2114 | - | expression tag |
| His 2115 | - | expression tag |
| His 2116 | - | expression tag |
| His 2117 | - | expression tag |
| His 2118 | - | expression tag |
| His 2119 | - | expression tag |
| His 2120 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gln 1118 | Pro 404 | engineered mutation |
B: 38 - 350 (UniProt: P19838)
| PDB | External Database | Details |
|---|---|---|
| Met 37 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 117736.9 | |
| All* | Total formula weight | 117736.9 |
