2O4N
Crystal Structure of HIV-1 Protease (TRM Mutant) in Complex with Tipranavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | protease | polymer | 99 | 10822.8 | 2 | UniProt (P03367) Pfam (PF00077) UniProt (by SIFTS) (Q90SN9) | Human immunodeficiency virus 1 | |
| 2 | C (A) | N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE | non-polymer | 602.7 | 1 | Chemie (TPV) | |||
| 3 | D (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 191 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 506 | engineered mutation |
| Val 13 | Ile 512 | engineered mutation |
| Ile 32 | Val 531 | engineered mutation |
| Phe 33 | Leu 532 | engineered mutation |
| Ile 45 | Lys 544 | engineered mutation |
| Leu 82 | Val 581 | engineered mutation |
| Val 84 | Ile 583 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21645.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 694.8 | |
| All* | Total formula weight | 22340.4 |
