2O36
Crystal structure of engineered thimet oligopeptidase with neurolysin specificity in neurotensin cleavage site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Thimet oligopeptidase | polymer | 674 | 77482.0 | 1 | UniProt (P52888) Pfam (PF01432) | Homo sapiens (human) | Endopeptidase 24.15, MP78 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | water | water | 18.0 | 471 | Chemie (HOH) |
Sequence modifications
A: 16 - 688 (UniProt: P52888)
| PDB | External Database | Details |
|---|---|---|
| Ser 246 | Cys 245 | engineered mutation |
| Ser 253 | Cys 252 | engineered mutation |
| Arg 469 | Glu 468 | engineered mutation |
| Thr 498 | Arg 497 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 77482.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 77547.4 |
