2O2N
Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Apoptosis regulator Bcl-X | polymer | 145 | 16085.9 | 1 | UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) In PDB | Homo sapiens (human) | Bcl-2-like 1 protein |
| 2 | A | 4-[4-(BIPHENYL-2-YLMETHYL)PIPERAZIN-1-YL]-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE | non-polymer | 735.9 | 1 | Chemie (LIW) |
Sequence modifications
A: 6 - 27 (UniProt: Q07817)
A: 37 - 200 (UniProt: Q07817)
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Ala 28 | - | insertion |
| Gly 29 | - | insertion |
| Gly 31 | - | insertion |
| Gly 32 | - | insertion |
| Gly 33 | - | insertion |
| Gly 29 | - | insertion |
| Gly 30 | - | insertion |
| Gly 31 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 16085.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 735.9 | |
| All* | Total formula weight | 16821.8 |
