2O21

Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Apoptosis regulator Bcl-2	polymer	164	19155.3	1	UniProt (P10415) UniProt (Q07817) Pfam (PF02180) Pfam (PF00452)	Homo sapiens (human)
2	B (A)	3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE	non-polymer		694.8	1	Chemie (43B)

Sequence modifications

A: 1 - 32 (UniProt: P10415)
A: 33 - 48 (UniProt: Q07817)
A: 89 - 204 (UniProt: P10415)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	19155.3
Non-Polymers*	Number of molecules	1
	Total formula weight	694.8
All*	Total formula weight	19850.1

*Water molecules are not included.