2NXL
Structure of HIV-1 protease D25N complexed with the rt-rh analogue peptide GLY-ALA-GLU-VAL-PHE*TYR-VAL-ASP-GLY-ALA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROTEASE RETROPEPSIN | polymer | 99 | 10814.8 | 2 | UniProt (O38732) Pfam (PF00077) UniProt (by SIFTS) (P03369) | HIV-1 M:B_ARV2/SF2 | HIV-1 PROTEASE |
| 2 | C (P) | Analogue of RT-RH pol protease substrate peptide | polymer | 10 | 1027.1 | 1 | |||
| 3 | D, E (B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | F, G, H (A, B, P) | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: O38732)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
| Asn 25 | Asp 25 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 22656.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 189.9 | |
| All* | Total formula weight | 22846.6 |
