2NXG
Structural and mechanistic changes along an engineered path from metallo to non-metallo KDO8P synthase.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 2-dehydro-3-deoxyphosphooctonate aldolase | polymer | 263 | 29281.7 | 2 | UniProt (O66496) Pfam (PF00793) | Aquifex aeolicus | Phospho-2- dehydro-3-deoxyoctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8- phosphate synthetase, KDO-8-phosphate synthetase, KDO 8-P synthase, KDOPS |
| 2 | C (A) | PHOSPHOENOLPYRUVATE | non-polymer | 168.0 | 1 | Chemie (PEP) | |||
| 3 | D (A) | ARABINOSE-5-PHOSPHATE | non-polymer | 232.1 | 1 | Chemie (A5P) | |||
| 4 | E (B) | (2R,4R,5R,6R,7R)-2,4,5,6,7-PENTAHYDROXY-2,8-BIS(PHOSPHONOOXY)OCTANOIC ACID | non-polymer | 416.2 | 1 | Chemie (1NT) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 222 | Chemie (HOH) |
Sequence modifications
A, B: 1002 - 1264 (UniProt: O66496)
| PDB | External Database | Details |
|---|---|---|
| Asn 1011 | Cys 11 | engineered mutation |
| Pro 1235 | Ser 235 | engineered mutation |
| Ala 1237 | Gln 237 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58563.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 816.3 | |
| All* | Total formula weight | 59379.8 |
