2NX1
Structural and mechanistic changes along an engineered path from metallo to non-metallo KDO8P synthase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 2-dehydro-3-deoxyphosphooctonate aldolase | polymer | 267 | 29785.4 | 2 | UniProt (O66496) Pfam (PF00793) | Aquifex aeolicus | Phospho-2-dehydro-3-deoxyoctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase, KDO-8-phosphate synthetase, KDO 8-P synthase, KDOPS |
| 2 | C, E (A, B) | 5-O-phosphono-beta-D-ribofuranose | non-polymer | 230.1 | 2 | Chemie (RP5) PubChem (23422546) PubChem (24802507) PubChem (439167) PubChem (440101) PubChem (447568) PubChem (447634) PubChem (448203) PubChem (46876838) PubChem (53477706) PubChem (4175041) PubChem (91746440) PubChem (13990819) PubChem (118070650) PubChem (11401949) PubChem (124350436) PubChem (168368775) PubChem (172642146) PubChem (167077165) PubChem (168366045) PubChem (172641724) | |||
| 3 | D, F (A, B) | PHOSPHOENOLPYRUVATE | non-polymer | 168.0 | 2 | Chemie (PEP) PubChem (1005) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 565 | Chemie (HOH) |
Sequence modifications
A, B: 1001 - 1267 (UniProt: O66496)
| PDB | External Database | Details |
|---|---|---|
| Asn 1011 | Cys 11 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59570.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 796.3 | |
| All* | Total formula weight | 60367.0 |
