2NS8
How an in vitro selected peptide mimics the antibiotic tetracycline to induce TET repressor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tetracycline repressor protein | polymer | 208 | 23531.7 | 4 | UniProt (P04483) UniProt (P0ACT4) Pfam (PF00440) Pfam (PF02909) | Escherichia coli | |
| 2 | E, F, G, H, I (H, E, F, G, Z) | 16 residue peptide Tip (Transcription inducing peptide) | polymer | 17 | 1668.8 | 5 | synthetic construct |
Sequence modifications
A, B, C, D: 1 - 187 (UniProt: P04483)
A, B, C, D: 188 - 208 (UniProt: P0ACT4)
| PDB | External Database | Details |
|---|---|---|
| Ser 68 | Cys 68 | engineered mutation |
| Asn 88 | Cys 88 | engineered mutation |
| Thr 121 | Cys 121 | engineered mutation |
| Ser 144 | Cys 144 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 102470.5 | |
| All* | Total formula weight | 102470.5 |
