2N7L

NMR structure of the N-domain of troponin C bound to the switch region of troponin I and the covalent levosimendan analog i9

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (C)	Troponin C/Troponin I chimera	polymer	141	16218.3	1	UniProt (P63316) UniProt (P19429) Pfam (PF13833)	Homo sapiens (human)	TN-C, Cardiac troponin I
2	B (C)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)

Sequence modifications

C: 1 - 89 (UniProt: P63316)

PDB	External Database	Details
Met -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
Gly -7	-	expression tag
Gly -6	-	expression tag
Leu -5	-	expression tag
Val -4	-	expression tag
Pro -3	-	expression tag
Arg -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Ser 35	Cys 35	engineered mutation
Glu 90	-	linker
Asn 91	-	linker
Leu 92	-	linker
Tyr 93	-	linker
Phe 94	-	linker
Gln 95	-	linker
Gly 96	-	linker

C: 97 - 126 (UniProt: P19429)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	16218.3
Non-Polymers*	Number of molecules	1
	Total formula weight	40.1
All*	Total formula weight	16258.4

*Water molecules are not included.