2MTP
The structure of Filamin repeat 21 bound to integrin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Filamin-A | polymer | 95 | 9762.7 | 1 | UniProt (P21333) Pfam (PF00630) In PDB | Homo sapiens (human) | FLN-A, Actin-binding protein 280, ABP-280, Alpha-filamin, Endothelial actin-binding protein, Filamin-1, Non-muscle filamin |
| 2 | B | Integrin alpha-IIb | polymer | 21 | 2581.8 | 1 | UniProt (P08514) Pfam (PF00357) In PDB | Homo sapiens (human) | GPalpha IIb, GPIIb, Platelet membrane glycoprotein IIb, Integrin alpha-IIb heavy chain, Integrin alpha-IIb light chain, form 1, Integrin alpha-IIb light chain, form 2 |
| 3 | C | Integrin beta-3 | polymer | 47 | 5618.3 | 1 | UniProt (P05106) Pfam (PF08725) In PDB | Homo sapiens (human) | Platelet membrane glycoprotein IIIa, GPIIIa |
Sequence modifications
C: 716 - 762 (UniProt: P05106)
| PDB | External Database | Details |
|---|---|---|
| Lys 717 | Leu 743 | engineered mutation |
| Lys 718 | Leu 744 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 17962.8 | |
| All* | Total formula weight | 17962.8 |
