2MH0

Solution NMR structure of the p300 Taz2:ETAD1 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Transcription factor E2-alpha	polymer	39	4267.9	1	UniProt (P15923)	Homo sapiens (human)	Class B basic helix-loop-helix protein 21, bHLHb21, Immunoglobulin enhancer-binding factor E12/E47, Immunoglobulin transcription factor 1, Kappa-E2-binding factor, Transcription factor 3, TCF-3, Transcription factor ITF-1
2	B (B)	Histone acetyltransferase p300	polymer	92	10107.9	1	UniProt (Q09472) Pfam (PF02135)	Homo sapiens (human)	p300 HAT, E1A-associated protein p300

Sequence modifications

A: 1 - 37 (UniProt: P15923)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag

B: 1723 - 1812 (UniProt: Q09472)

PDB	External Database	Details
Gly 1721	-	expression tag
Ser 1722	-	expression tag
Ala 1738	Cys 1738	engineered mutation
Ala 1746	Cys 1746	engineered mutation
Ala 1789	Cys 1789	engineered mutation
Ala 1790	Cys 1790	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	14375.8
All*	Total formula weight	14375.8

*Water molecules are not included.