2M7H

The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrin alpha-IIb beta-3 Recognition

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Zinc metalloproteinase/disintegrin	polymer	79	8759.8	1	UniProt (P30403) Pfam (PF00200) In PDB	Calloselasma rhodostoma (Malayan pit viper)	Snake venom metalloproteinase rhodostoxin, SVMP, Hemorrhagic protein, Disintegrin rhodostomin, RHO, Disintegrin kistrin, Platelet aggregation activation inhibitor

Sequence modifications

A: 1 - 71 (UniProt: P30403)

PDB	External Database	Details
Glu -7	-	EXPRESSION TAG
Phe -6	-	EXPRESSION TAG
His -5	-	EXPRESSION TAG
His -4	-	EXPRESSION TAG
His -3	-	EXPRESSION TAG
His -2	-	EXPRESSION TAG
His -1	-	EXPRESSION TAG
His 0	-	EXPRESSION TAG
Ala 48	Pro 455	ENGINEERED MUTATION
Trp 52	Met 459	ENGINEERED MUTATION
Asn 53	Pro 460	ENGINEERED MUTATION
Asn 67	Tyr 474	ENGINEERED MUTATION
Pro 68	His 475	ENGINEERED MUTATION
Trp 69	Ser 476	ENGINEERED MUTATION
Asn 70	His 477	ENGINEERED MUTATION
Gly 71	Ala 478	ENGINEERED MUTATION

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	8759.8
All*	Total formula weight	8759.8

*Water molecules are not included.