2KAV

Solution structure of the human Voltage-gated Sodium Channel, brain isoform (Nav1.2)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Sodium channel protein type 2 subunit alpha	polymer	129	14591.4	1	UniProt (Q99250)	Homo sapiens (human)	Sodium channel protein type II subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.2, Sodium channel protein, brain II subunit alpha, HBSC II

Sequence modifications

A: 1777 - 1882 (UniProt: Q99250)

PDB	External Database	Details
Met 1754	-	expression tag
Gly 1755	-	expression tag
Ser 1756	-	expression tag
Ser 1757	-	expression tag
His 1758	-	expression tag
His 1759	-	expression tag
His 1760	-	expression tag
His 1761	-	expression tag
His 1762	-	expression tag
His 1763	-	expression tag
Ser 1764	-	expression tag
Ser 1765	-	expression tag
Gly 1766	-	expression tag
Leu 1767	-	expression tag
Val 1768	-	expression tag
Pro 1769	-	expression tag
Arg 1770	-	expression tag
Gly 1771	-	expression tag
Ser 1772	-	expression tag
His 1773	-	expression tag
Met 1774	-	expression tag
Ala 1775	-	expression tag
Ser 1776	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	14591.4
All*	Total formula weight	14591.4

*Water molecules are not included.