2JJP
Structure of cytochrome P450 EryK in complex with inhibitor ketoconazole (KC)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CYTOCHROME P450 113A1 | polymer | 411 | 45347.0 | 1 | UniProt (P48635) Pfam (PF00067) | SACCHAROPOLYSPORA ERYTHRAEA | ERYTHROMYCIN B/D C-12 HYDROXYLASE, CYTOCROME P450 CYP113A1 |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | 1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZINE | non-polymer | 531.4 | 1 | Chemie (KLN) | |||
| 4 | D, E (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | F (A) | water | water | 18.0 | 229 | Chemie (HOH) |
Sequence modifications
A: 1 - 14 (PDB: 2JJP)
A: 15 - 411 (UniProt: P48635)
A: 15 - 411 (UniProt: P48635)
| PDB | External Database | Details |
|---|---|---|
| Leu 15 | Met 1 | engineered mutation |
| Leu 344 | Phe 330 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45347.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1340.0 | |
| All* | Total formula weight | 46687.1 |
