2JIT

Crystal structure of EGFR kinase domain T790M mutation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	EPIDERMAL GROWTH FACTOR RECEPTOR	polymer	327	37334.2	2	UniProt (P00533) Pfam (PF07714)	HOMO SAPIENS (HUMAN)	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1
2	C, D (A, B)	water	water		18.0	73	Chemie (HOH)

Sequence modifications

A, B: 696 - 1022 (UniProt: P00533)

PDB	External Database	Details
Met 790	Thr 790	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74668.4
All*	Total formula weight	74668.4

*Water molecules are not included.