2JED
The crystal structure of the kinase domain of the protein kinase C theta in complex with NVP-XAA228 at 2.32A resolution.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | PROTEIN KINASE C THETA | polymer | 352 | 41824.0 | 2 | UniProt (Q04759) Pfam (PF00069) Pfam (PF00433) In PDB | HOMO SAPIENS (HUMAN) | NPKC-THETA |
| 2 | A, B | 3-(8-DIMETHYLAMINOMETHYL-6,7,8,9-TETRAHYDRO-PYRIDO[1,2-A]INDOL-10-YL)-4-(1-METHYL-1H-INDOL-3-YL)-PYRROLE-2,5-DIONE | non-polymer | 452.5 | 2 | Chemie (LG8) | |||
| 3 | B | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 4 | water | water | 18.0 | 412 | Chemie (HOH) |
Sequence modifications
A, B: 361 - 706 (UniProt: Q04759)
A, B: 707 - 712 (PDB: 2JED)
| PDB | External Database | Details |
|---|---|---|
| Glu 381 | Ile 381 | engineered mutation |
| Glu 538 | Thr 538 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 83647.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1023.3 | |
| All* | Total formula weight | 84671.2 |
