2JCX
X-ray structure of mutant 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with fosmidomycin and NADPH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE | polymer | 398 | 41699.0 | 2 | UniProt (P64012) Pfam (PF02670) Pfam (PF08436) Pfam (PF13288) UniProt (by SIFTS) (P9WNS1) In PDB | MYCOBACTERIUM TUBERCULOSIS | DXP REDUCTOISOMERASE, 1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERASE, 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE SYNTHASE |
| 2 | A | 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID | non-polymer | 183.1 | 1 | Chemie (FOM) | |||
| 3 | A, B | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 4 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | water | water | 18.0 | 440 | Chemie (HOH) |
Sequence modifications
A, B: -8 - 1 (PDB: 2JCX)
A, B: 2 - 389 (UniProt: P64012)
A, B: 2 - 389 (UniProt: P64012)
| PDB | External Database | Details |
|---|---|---|
| Asn 151 | Asp 151 | engineered mutation |
| Gln 222 | Glu 222 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 83398.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1866.1 | |
| All* | Total formula weight | 85264.1 |
