2JCV

X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with fosmidomycin and NADPH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE	polymer	398	41701.0	2	UniProt (P64012) Pfam (PF02670) Pfam (PF08436) Pfam (PF13288) UniProt (by SIFTS) (P9WNS1) In PDB	MYCOBACTERIUM TUBERCULOSIS	DXP REDUCTOISOMERASE, 1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERASE, 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE SYNTHASE
2	A	3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID	non-polymer		183.1	1	Chemie (FOM)
3	A, B	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
4	A, B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5		water	water		18.0	521	Chemie (HOH)

Sequence modifications

A, B: -8 - 1 (PDB: 2JCV)
A, B: 2 - 389 (UniProt: P64012)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	83401.9
Non-Polymers*	Number of molecules	5
	Total formula weight	1866.1
All*	Total formula weight	85268.0

*Water molecules are not included.