2JC1
CRYSTAL STRUCTURE OF HEPATITIS C VIRUS POLYMERASE IN COMPLEX WITH INHIBITOR SB698223
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | RNA-DEPENDENT RNA-POLYMERASE | polymer | 570 | 63332.7 | 2 | UniProt (O39930) Pfam (PF00998) UniProt (by SIFTS) (P26663) | HEPATITIS C VIRUS | HEPATITIS C VIRUS RNA POLYMERASE |
| 2 | C, D (A, B) | (2S,4S,5R)-1-(4-TERT-BUTYLBENZOYL)-2-ISOBUTYL-5-(1,3-THIAZOL-2-YL)PYRROLIDINE-2,4-DICARBOXYLIC ACID | non-polymer | 458.6 | 2 | Chemie (698) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 654 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 570 (UniProt: O39930)
| PDB | External Database | Details |
|---|---|---|
| His 120 | Arg 120 | conflict |
| Val 131 | Glu 131 | conflict |
| Val 185 | Ala 185 | conflict |
| Asn 213 | Cys 213 | conflict |
| Lys 254 | Arg 254 | conflict |
| Asn 316 | Cys 316 | conflict |
| Val 329 | Thr 329 | conflict |
| Val 338 | Ala 338 | conflict |
| Glu 464 | Gln 464 | conflict |
| Lys 531 | Arg 531 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 126665.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 917.1 | |
| All* | Total formula weight | 127582.5 |
