2J90

Crystal structure of human ZIP kinase in complex with a tetracyclic pyridone inhibitor (Pyridone 6)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	DEATH-ASSOCIATED PROTEIN KINASE 3	polymer	304	35176.7	2	UniProt (O43293) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	DAP KINASE 3, DAP-LIKE KINASE, DLK, ZIP KINASE
2	C, F (A, B)	2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE	non-polymer		309.3	2	Chemie (IZA)
3	D, G (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	E, H, I (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
5	J (B)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
6	K, L (A, B)	water	water		18.0	327	Chemie (HOH)

Sequence modifications

A, B: -22 - 0 (PDB: 2J90)
A, B: 9 - 289 (UniProt: O43293)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70353.5
Non-Polymers*	Number of molecules	8
	Total formula weight	970.8
All*	Total formula weight	71324.2

*Water molecules are not included.