2J50

Structure of Aurora-2 in complex with PHA-739358

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	SERINE/THREONINE-PROTEIN KINASE 6	polymer	280	32369.1	2	UniProt (O14965) Pfam (PF00069) In PDB	HOMO SAPIENS (HUMAN)	SERINE/THREONINE KINASE 15, AURORA/IPL1-RELATED KINASE 1, AURORA-RELATED KINASE 1, HARK1, AURORA-A, BREAST-TUMOR-AMPLIFIED KINASE
2	A, B	N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE	non-polymer		474.6	2	Chemie (627)
3	A, B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)

Sequence modifications

A, B: 124 - 125 (PDB: 2J50)
A, B: 126 - 403 (UniProt: O14965)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	64738.2
Non-Polymers*	Number of molecules	4
	Total formula weight	1141.2
All*	Total formula weight	65879.4

*Water molecules are not included.