2J32
The Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of(Pro)caspase-3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CASPASE-3 | polymer | 250 | 28612.6 | 1 | UniProt (P42574) Pfam (PF00656) | HOMO SAPIENS (HUMAN) | CASP-3, APOPAIN, CYSTEINE PROTEASE CPP32, CPP-32, PROTEIN YAMA, SREBP CLEAVAGE ACTIVITY 1, SCA-1, CASPASE-3 SUBUNIT P17, CASPASE-3 SUBUNIT P12 |
| 2 | B (B) | ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR | polymer | 6 | 534.9 | 1 | BIRD (PRD_000238) | SYNTHETIC CONSTRUCT | AC-DEVD-CMK |
| 3 | C, D (A, B) | water | water | 18.0 | 306 | Chemie (HOH) |
Sequence modifications
A: 29 - 277 (UniProt: P42574)
| PDB | External Database | Details |
|---|---|---|
| Ala 173 | Glu 173 | engineered mutation |
| His 278 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29147.6 | |
| All* | Total formula weight | 29147.6 |
