2J1Y
Human p53 core domain mutant M133L-V203A-N239Y-G245S-N268D
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | CELLULAR TUMOR ANTIGEN P53 | polymer | 200 | 22539.6 | 4 | UniProt (P04637) Pfam (PF00870) In PDB | HOMO SAPIENS (HUMAN) | P53, TUMOR SUPPRESSOR P53, PHOSPHOPROTEIN P53, ANTIGEN NY-CO-13 |
| 2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | A, B, C, D | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 4 | water | water | 18.0 | 754 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 94 - 293 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Leu 133 | Met 133 | engineered mutation |
| Ala 203 | Val 203 | engineered mutation |
| Tyr 239 | Asn 239 | engineered mutation |
| Ser 245 | Gly 245 | engineered mutation |
| Asp 268 | Asn 268 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 90158.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 421.9 | |
| All* | Total formula weight | 90580.2 |
