2IW9
STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | CELL DIVISION PROTEIN KINASE 2 | polymer | 302 | 34326.7 | 2 | UniProt (P24941) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | CYCLIN DEPENDENT KINASE 2, P33 PROTEIN KINASE |
| 2 | B, D (B, D) | CYCLIN-A2 | polymer | 260 | 29884.6 | 2 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) | HOMO SAPIENS (HUMAN) | HUMAN CYCLIN A, CYCLIN-A |
| 3 | E, H (A, C) | O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE | non-polymer | 402.5 | 2 | Chemie (4SP) | |||
| 4 | F, I (B, D) | MONOTHIOGLYCEROL | non-polymer | 108.2 | 2 | Chemie (SGM) | |||
| 5 | G, J (B, D) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 384 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
B, D: 174 - 432 (UniProt: P20248)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Thr 89 | Lys 89 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 173 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 128422.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1069.9 | |
| All* | Total formula weight | 129492.5 |
