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2IW6

STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, CCELL DIVISION PROTEIN KINASE 2polymer30234326.72UniProt (P24941)
Pfam (PF00069)
In PDB
HOMO SAPIENS (HUMAN)CYCLIN DEPENDENT KINASE 2, P33 PROTEIN KINASE
2B, DCYCLIN-A2polymer26029884.62UniProt (P20248)
Pfam (PF00134)
Pfam (PF02984)
In PDB
HOMO SAPIENS (HUMAN)HUMAN CYCLIN A, CYCLIN-A
3A, C[(2-CHLORO-5-METHYLPHENYL){6-[(4-{[(2R)-3-(DIMETHYLAMINO)-2-HYDROXYPROPYL]OXY}PHENYL)AMINO]PYRIMIDIN-4-YL}AMINO]ACETONITRILEnon-polymer467.02Chemie (QQ2)
4B, DMONOTHIOGLYCEROLnon-polymer108.22Chemie (SGM)
5BMAGNESIUM IONnon-polymer24.31Chemie (MG)
6waterwater18.0114Chemie (HOH)
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
PDBExternal DatabaseDetails
Gly -3-expression tag
Pro -2-expression tag
Gly -1-expression tag
Ser 0-expression tag
Thr 89Lys 89engineered mutation
B, D: 174 - 432 (UniProt: P20248)
PDBExternal DatabaseDetails
Met 173-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight128422.6
Non-Polymers*Number of molecules5
Total formula weight1174.5
All*Total formula weight129597.1
*Water molecules are not included.

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PDB entries from 2024-09-11

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