2IVU
Crystal structure of phosphorylated RET tyrosine kinase domain complexed with the inhibitor ZD6474
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR | polymer | 314 | 35788.2 | 1 | UniProt (P07949) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | RET RECEPTOR, C-RET |
| 2 | B, C (A) | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
| 3 | D (A) | Vandetanib | non-polymer | 475.4 | 1 | Chemie (ZD6) | |||
| 4 | E (A) | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35788.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 567.4 | |
| All* | Total formula weight | 36355.6 |
