2ITQ
Crystal structure of EGFR kinase domain G719S mutation in complex with AFN941
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | EPIDERMAL GROWTH FACTOR RECEPTOR | polymer | 327 | 37334.2 | 1 | UniProt (P00533) Pfam (PF07714) | HOMO SAPIENS | RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1 |
| 2 | B (A) | 1,2,3,4-Tetrahydrogen Staurosporine | non-polymer | 468.5 | 1 | Chemie (ITQ) | |||
| 3 | C (A) | water | water | 18.0 | 57 | Chemie (HOH) |
Sequence modifications
A: 696 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Ser 719 | Gly 719 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37334.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 468.5 | |
| All* | Total formula weight | 37802.7 |
