2ITO
Crystal structure of EGFR kinase domain G719S mutation in complex with Iressa
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | EPIDERMAL GROWTH FACTOR RECEPTOR | polymer | 327 | 37334.2 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1 |
2 | A | Gefitinib | non-polymer | 446.9 | 1 | Chemie (IRE) | |||
3 | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence modifications
A: 696 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Ser 719 | Gly 719 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37334.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 446.9 | |
All* | Total formula weight | 37781.1 |