2IRW
Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Ether Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | polymer | 264 | 29040.8 | 8 | UniProt (P28845) Pfam (PF00106) | Homo sapiens (human) | 11-DH, 11-beta-hydroxysteroid dehydrogenase 1, 11-beta-HSD1 |
| 2 | I, K, M, O, Q... (A, B, C, D, E...) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 8 | Chemie (NAP) | |||
| 3 | J, L, N, P, R... (A, B, C, D, E...) | (1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE | non-polymer | 386.5 | 8 | Chemie (NN4) |
Sequence modifications
A, B, C, D, E, F, G, H: 26 - 289 (UniProt: P28845)
| PDB | External Database | Details |
|---|---|---|
| Ser 272 | Cys 271 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 232326.4 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 9039.1 | |
| All* | Total formula weight | 241365.5 |
