2IPJ
Crystal structure of h3alpha-hydroxysteroid dehydrogenase type 3 mutant Y24A in complex with NADP+ and epi-testosterone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Aldo-keto reductase family 1 member C2 | polymer | 321 | 36447.9 | 2 | UniProt (P52895) Pfam (PF00248) | Homo sapiens (human) | Trans-1,2- dihydrobenzene-1,2-diol dehydrogenase, Type III 3- alpha-hydroxysteroid dehydrogenase, 3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase/bile acid-binding protein, DD/BABP, Dihydrodiol dehydrogenase 2, DD2 |
| 2 | C, K, L (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | D, M (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 4 | E, N (A, B) | (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE | non-polymer | 288.4 | 2 | Chemie (FFA) | |||
| 5 | F, G, O (A, B) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 3 | Chemie (BME) | |||
| 6 | H, I, J, P, Q... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 7 | T, U (A, B) | water | water | 18.0 | 613 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 323 (UniProt: P52895)
| PDB | External Database | Details |
|---|---|---|
| Ala 24 | Tyr 24 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72895.8 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 3020.7 | |
| All* | Total formula weight | 75916.5 |
