2IPG
Crystal structure of 17alpha-hydroxysteroid dehydrogenase mutant K31A in complex with NADP+ and epi-testosterone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 3(17)alpha-hydroxysteroid dehydrogenase | polymer | 319 | 36404.9 | 2 | UniProt (Q91WR5) Pfam (PF00248) | Mus musculus (Mouse) | |
| 2 | C, I (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | D, J (A, B) | (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE | non-polymer | 288.4 | 2 | Chemie (FFA) | |||
| 4 | E, F, K, L (A, B) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 4 | Chemie (BME) | |||
| 5 | G, H, M (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 6 | N, O (A, B) | water | water | 18.0 | 481 | Chemie (HOH) |
Sequence modifications
A, B: 5 - 323 (UniProt: Q91WR5)
| PDB | External Database | Details |
|---|---|---|
| Ala 31 | Lys 31 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72809.9 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2562.4 | |
| All* | Total formula weight | 75372.3 |
