2ICW
Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 179 | 20983.2 | 2 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen DRA |
| 2 | B, E (B, E) | HLA class II histocompatibility antigen, DRB1-1 beta chain | polymer | 190 | 22080.7 | 2 | UniProt (P04229) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911) | Homo sapiens (human) | MHC class II antigen DRB1*1, DR-1, DR1 |
| 3 | C, F (C, F) | haemagglutinin peptide | polymer | 13 | 1506.8 | 2 | |||
| 4 | G, H (G, H) | Mycoplasma arthritidis mitogen | polymer | 213 | 25332.3 | 2 | UniProt (Q48898) Pfam (PF09245) | Mycoplasma arthritidis | |
| 5 | I, K (I, K) | T-cell receptor alpha chain V | polymer | 110 | 12113.6 | 2 | UniProt (P01738) Pfam (PF07686) | Mus musculus (house mouse) | |
| 6 | J, L (J, L) | T-cell receptor beta chain V | polymer | 113 | 12184.3 | 2 | UniProt (P04213) Pfam (PF07686) UniProt (by SIFTS) (A2NTY6) | Mus musculus (house mouse) | |
| 7 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 305 | Chemie (HOH) |
Sequence modifications
A, D: 3 - 181 (UniProt: P01903)
I, K: 1 - 110 (UniProt: P01738)
J, L: 1 - 80 (UniProt: P04213)
| PDB | External Database | Details |
|---|---|---|
| Mse 23 | Met 48 | modified residue |
| Mse 36 | Met 61 | modified residue |
| Mse 73 | Met 98 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| Pro 43 | Leu 63 | engineered mutation |
| Arg 82 | Trp 102 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 10 | Ser 18 | SEE REMARK 999 |
| Glu 17 | Gly 25 | engineered mutation |
| Asn 24 | His 32 | SEE REMARK 999 |
| Asn 30 | Asp 38 | SEE REMARK 999 |
| Asn 31 | Tyr 39 | SEE REMARK 999 |
| Glu 42 | Gly 50 | engineered mutation |
| Gly 51 | Val 59 | SEE REMARK 999 |
| Gly 53 | Asp 61 | SEE REMARK 999 |
| Ser 80 | Leu 88 | engineered mutation |
| Ala 81 | - | SEE REMARK 999 |
| Thr 82 | - | SEE REMARK 999 |
| Pro 83 | - | SEE REMARK 999 |
| Ser 84 | - | SEE REMARK 999 |
| Gln 85 | - | SEE REMARK 999 |
| Thr 86 | - | SEE REMARK 999 |
| Ser 87 | - | SEE REMARK 999 |
| Val 88 | - | SEE REMARK 999 |
| Tyr 89 | - | SEE REMARK 999 |
| Phe 90 | - | SEE REMARK 999 |
| Cys 91 | - | SEE REMARK 999 |
| Ala 92 | - | SEE REMARK 999 |
| Ser 93 | - | SEE REMARK 999 |
| Gly 94 | - | SEE REMARK 999 |
| Gly 95 | - | SEE REMARK 999 |
| Gly 96 | - | SEE REMARK 999 |
| Gly 97 | - | SEE REMARK 999 |
| Thr 98 | - | SEE REMARK 999 |
| Tyr 100 | - | SEE REMARK 999 |
| Phe 101 | - | SEE REMARK 999 |
| Gly 102 | - | SEE REMARK 999 |
| Ala 103 | - | SEE REMARK 999 |
| Gly 104 | - | SEE REMARK 999 |
| Thr 105 | - | SEE REMARK 999 |
| Arg 106 | - | SEE REMARK 999 |
| Leu 107 | - | SEE REMARK 999 |
| Ser 108 | - | SEE REMARK 999 |
| Val 109 | - | SEE REMARK 999 |
| Leu 110 | - | SEE REMARK 999 |
| Ser 111 | - | cloning artifact |
| Ser 112 | - | cloning artifact |
| Ala 113 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 188401.8 | |
| All* | Total formula weight | 188401.8 |
