2ICA
CD11a (LFA1) I-domain complexed with BMS-587101 aka 5-[(5S, 9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro [4.4]non-7-yl]methyl]-3-thiophenecarboxylicacid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrin alpha-L | polymer | 183 | 20936.0 | 1 | UniProt (P20701) Pfam (PF00092) | Homo sapiens (human) | Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, CD11a antigen |
| 2 | B (A) | 5-[(5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL)-1-METHYL-2,4-DIOXO-1,3,7-TRIAZASPIRO [4.4]NON-7-YL]METHYL]-3-THIOPHENECARBOXYLICACID | non-polymer | 555.4 | 1 | Chemie (2IC) | |||
| 3 | C (A) | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
A: 129 - 307 (UniProt: P20701)
| PDB | External Database | Details |
|---|---|---|
| Gly 125 | - | cloning artifact |
| Ser 126 | - | cloning artifact |
| His 127 | - | cloning artifact |
| Met 128 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 20936.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 555.4 | |
| All* | Total formula weight | 21491.4 |
