2IBW
Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase (T2): the importance of potassium and chloride for its structure and function
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Acetyl-CoA acetyltransferase | polymer | 395 | 41549.0 | 4 | UniProt (P24752) Pfam (PF00108) Pfam (PF02803) | Homo sapiens (human) | Acetoacetyl-CoA thiolase, T2 |
| 2 | E, J, M, P (A, B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 3 | F, K, N, Q (A, B, C, D) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 4 | G, L, O, R (A, B, C, D) | COENZYME A | non-polymer | 767.5 | 4 | Chemie (COA) | |||
| 5 | H (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 6 | I (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 1100 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 34 - 427 (UniProt: P24752)
| PDB | External Database | Details |
|---|---|---|
| Met 33 | - | initiating methionine |
| Ala 34 | Val 34 | engineered mutation |
| Cso 126 | Cys 126 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 166196.2 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 3655.7 | |
| All* | Total formula weight | 169851.9 |
