2I65
Structural Basis for the Mechanistic Understanding Human CD38 Controlled Multiple Catalysis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | ADP-ribosyl cyclase 1 | polymer | 262 | 30379.4 | 2 | UniProt (P28907) Pfam (PF02267) | Homo sapiens (human) | Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, Lymphocyte differentiation antigen CD38, T10, Acute lymphoblastic leukemia cells antigen CD38 |
| 2 | C, D (A, B) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 2 | Chemie (NAD) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 215 | Chemie (HOH) |
Sequence modifications
A, B: 45 - 300 (UniProt: P28907)
| PDB | External Database | Details |
|---|---|---|
| Lys 39 | - | cloning artifact |
| Arg 40 | - | cloning artifact |
| Glu 41 | - | cloning artifact |
| Ala 42 | - | cloning artifact |
| Glu 43 | - | cloning artifact |
| Ala 44 | - | cloning artifact |
| Thr 49 | Gln 49 | engineered mutation |
| Asp 100 | Asn 100 | engineered mutation |
| Asp 164 | Asn 164 | engineered mutation |
| Asp 209 | Asn 209 | engineered mutation |
| Asp 219 | Asn 219 | engineered mutation |
| Gln 226 | Glu 226 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 60758.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1326.8 | |
| All* | Total formula weight | 62085.7 |
