2I4P
Crystal structure of the complex between PPARgamma and the partial agonist LT127 (ureidofibrate derivative). Structure obtained from crystals of the apo-form soaked for 30 days.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Peroxisome proliferator-activated receptor gamma | polymer | 286 | 32530.7 | 2 | UniProt (P37231) Pfam (PF00104) In PDB | Homo sapiens (human) | PPAR-gamma |
2 | A | (2S)-2-(4-{2-[1,3-BENZOXAZOL-2-YL(HEPTYL)AMINO]ETHYL}PHENOXY)-2-METHYLBUTANOIC ACID | non-polymer | 452.6 | 1 | Chemie (DRH) | |||
3 | water | water | 18.0 | 113 | Chemie (HOH) |
Sequence modifications
A, B: 195 - 476 (UniProt: P37231)
PDB | External Database | Details |
---|---|---|
Gly 191 | - | cloning artifact |
Ser 192 | - | cloning artifact |
His 193 | - | cloning artifact |
Met 194 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 65061.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 452.6 | |
All* | Total formula weight | 65513.9 |